Yes, you can just as well run from local files. You can replace the path to GitHub with a path to a directory in your system. That works for the run command and also the describe command.
A complete command looks like this:
botengine run E:\Repos\bots\implement\applications\eve-online\eve-online-mining-bot
When you want to download the files from GitHub, you can use the “Download ZIP” link in the GitHub GUI. Another way to get the app files is to extract them out of any session recording archive.